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產(chǎn)品規(guī)格
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BN41330R-100ul
100ul
￥2360.00
交叉反應：Mouse,Rat(predicted:Human,Pig,Rabbit) 推薦應用：WB,ELISA
BN41330R-200ul
200ul
￥3490.00
交叉反應：Mouse,Rat(predicted:Human,Pig,Rabbit) 推薦應用：WB,ELISA
產(chǎn)品描述
| 英文名稱 | FBXO25 |
| 中文名稱 | F-box蛋白家族FBXO25抗體 |
| 別 名 | F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25; MGC20256; MGC51975; OTTHUMP00000115399; |
| 研究領域 | 細胞生物 免疫學 信號轉導 轉錄調(diào)節(jié)因子 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Pig, Rabbit, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXO25:55-150/367 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | FBXO25 is a member of the F box protein family which is characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1 cullin F box), which function in phosphorylation dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD 40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein protein interaction modules or no recognizable motifs. FBXO25 belongs to the Fbxs class. There are three named isoforms produced by alternative splicing. FBXO25, also known as FBX25, is a 367 amino acid protein that contains one C-terminal F-box domain and belongs to the Fbx class of the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Expressed at high levels in brain, FBXO25 localizes predominantly to the nucleus and directly interacts with Skp1 p19 and CUL-1. Disruption of the gene encoding FBXO25 can lead to X-linked mental retardation. Function: Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ)protein huntingtin (HTT) (By similarity). Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complexconsisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly withSKP1 and CUL1. Interacts (via C-terminus) with beta-actin (viaN-terminus). Subcellular Location: Nuclear. Note=In the nucleus, associateswith a subnuclear dot-like structure. Colocalized with SKP1 Tissue Specificity: Expressed in all brain tissue observed. DISEASE: Note=A chromosomal aberration involving FBXO25 is a causeof X-linked mental retardation (XLMR). Translocationt(X;8)(p11.22;p23.3) with SHROOM4. Similarity: Contains 1 F-box domain. SWISS: Q8TCJ0 Gene ID: 26260 Database links: Entrez Gene: 26260 Human Entrez Gene: 66822 Mouse Omim: 609098 Human SwissProt: Q8TCJ0 Human SwissProt: Q9D2Y6 Mouse Unigene: 438454 Human Unigene: 37950 Mouse Unigene: 3663 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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