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BN41520R-50ul
50ul
￥1486.00
交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41520R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41520R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | PPAR delta + beta |
| 中文名稱 | D型-過氧化酶活化增生受體抗體 |
| 別 名 | PPAR delta+beta; FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN. |
| 研究領(lǐng)域 | 心血管 免疫學(xué) 細胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse PPAR-delta:2-100/440 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain. Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous with maximal levels in placenta and skeletal muscle. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P35396 Gene ID: 5467 Database links: Entrez Gene: 5467 Human Entrez Gene: 19015 Mouse Omim: 600409 Human SwissProt: Q03181 Human SwissProt: P35396 Mouse Unigene: 696032 Human Unigene: 328914 Mouse Unigene: 96181 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 類固醇受體（Steroid Receptors） 研究人員指出該分子的功能，極可能就是阻斷心血管免疫發(fā)炎反應(yīng)的訊號傳遞過程。PPAR－delta基因是控制肌肉發(fā)展的重要基因，在增加老鼠耐力的同時還能幫助它燃燒掉脂肪，研究人員發(fā)現(xiàn)，對于與新陳代謝有關(guān)的各項疾病，從心臟病到肥胖癥都有啟發(fā)性的意義，他可以阻止脂肪沉淀在動脈壁上，進而防止動脈硬化癥的發(fā)生,該蛋白參與脂肪代謝、肥胖、糖尿病、動脈硬化和癌癥的發(fā)病。 在動脈硬化現(xiàn)象發(fā)生的早期，免疫細胞會促使血管慢性的發(fā)炎，因而造成血管不斷地吸收和輸送脂肪，進而導(dǎo)致脂肪的堆積與血管硬化，而PPAR-delta就像警衛(wèi)分子一樣，時時降低發(fā)炎反應(yīng)和抑制動脈硬化斑的形成，因此該分子應(yīng)該是相關(guān)藥物研發(fā)，相當(dāng)值得切入的目標(biāo)。 研究人員認為，這個發(fā)現(xiàn)將給藥廠研發(fā)治療心血管疾病的新藥提供新的線索。 |
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